People with the most common type of lung cancer whose disease has spread to the brain could be spared potentially harmful whole brain radiotherapy, according to new research published in The Lancet.

Panelists discuss how the 5-year CROWN trial data for lorlatinib have shaped the treatment paradigm for ALK+ metastatic non-small cell lung cancer (NSCLC), particularly regarding long-term survival, ...

Brain metastases often occur as a result of advanced cancer and, despite medical innovations, are still associated with a poor prognosis. Now, an international expert committee has taken an important ...

Like a bouncer guarding the entrance to an exclusive nightclub, the blood-brain barrier - a dense layer of cells surrounding ...

Brain metastases arising from gynecologic cancers, including ovarian, endometrial and cervical malignancies, present unique diagnostic and therapeutic challenges. Although these metastatic events are ...

A study at two US medical centers found that patients with brain metastases from gastrointestinal (GI) cancers had significantly worse overall survival and intracranial progression-free survival (PFS) ...

A phase 2 trial found that compared with whole brain radiation (WBRT), stereotactic radiation reduced neurologic deaths in patients with small cell lung cancer (SCLC) and 1-10 brain metastases. SCLC ...

“This case challenges current paradigms, demonstrating that amivantamab monotherapy can effectively target rare EGFR mutations, achieve durable extracranial and CNS disease control, and potentially ...

Stage 4 lung cancer, also called metastatic lung cancer, is the most aggressive and life-threatening stage of the disease. By this point, cancer has spread from the lungs to vital organs such as the ...

RAD101 targets fatty acid synthase, overexpressed in many solid tumors, to improve brain metastases imaging. Fast track designation by the FDA accelerates development for treatments addressing unmet ...