Deep inside a small, windowless room at the University of California, Berkeley, two microscopes are quietly capturing some of the most detailed views of life ever recorded. Day and night, they collect ...

Single-Molecule Localization Microscopy (SMLM) has traditionally faced challenges to optimize signal-to-noise ratio, penetration depth, field-of-view (FOV), and spatial resolution simultaneously. Here ...

Expansion microscopy (ExM) 1 physically magnifies preserved biological specimens by covalently anchoring biomolecules and/or their labels to a swellable polymer network (such as sodium polyacrylate) ...

Both for research and medical purposes, researchers have spent decades pushing the limits of microscopy to produce ever deeper and sharper images of brain activity, not only in the cortex but also in ...

For biologists, seeing is believing. But sometimes biologists have a hard time seeing. One particularly vexing challenge is seeing all the molecules in an intact tissue sample, down to the level of ...

Trinity College Dublin now has Ireland's first and only BioBrillouin microscope, which will enable researchers to make giant strides in the fields of inflammation, cancer, developmental biology and ...

Researchers at Helmholtz Munich and the Technical University of Munich have developed a new microscope that significantly improves how bioluminescent signals in living cells can be observed. The ...

A hybrid microscope allows scientists to simultaneously image the full 3D orientation and position of an ensemble of molecules, such as labeled proteins inside cells. The microscope combines polarized ...

An AI-driven approach converts micro-CT scans into virtual histological stains, enabling 3D visualization of tissue structure ...

Dissociating tissues into single cells is a core laboratory technique and vital for widely used applications such as next-generation sequencing or flow cytometry. Scientists who employ tissue ...

Immune responses rely on the efficient movement of immune cells within the complex and geometrically unpredictable three-dimensional tissues that make up our bodies. Recent research by the Sixt group ...