DNA polymerases orchestrate the faithful replication and repair of genomes through a coordinated sequence of substrate binding, chemical catalysis and product release. Central to this process are ...

Accurate duplication of the genome is fundamental to cellular viability and prevention of disease. Replicative DNA polymerases achieve high fidelity through three interconnected mechanisms: intrinsic ...

Red arrows indicate the DNA repair pathways that are known to aid bacterial survival as persisters and gamblers in the presence of fluoroquinolones. Blue color arrow indicates downregulation, while ...

Researchers at the Department of Energy's SLAC National Accelerator Laboratory have uncovered new insights into the fundamental mechanisms of RNA polymerase II (Pol II), the protein responsible for ...

DNA repair proteins act like the body's editors, constantly finding and reversing damage to our genetic code. Researchers have long struggled to understand how cancer cells hijack one of these ...