Combining Ritual and Invocation Runes creates Runewords with specific effects in Diablo 4. The Vessel of Hatred expansion added new Runewords and updated existing ones, shaking up the Season 7 meta.

In this Diablo 4 guide, we’ll give you a full “Poison in the Roots” walkthrough, including showing you how to navigate through the ritual puzzle. When you turn in enough Grim Favors (by ...