Enzyme-blocking treatment reverses chronic pain in preclinical study

Chronic pain affects more than 50 million Americans, yet for decades, treatment options for pain that persists in the absence ...
ascopubs.org

Evaluation of MLN4924, an investigational NEDD8-activating enzyme (NAE) inhibitor, as a novel targeted agent with single-agent antitumor activity in mantle cell lymphoma (MCL ...

Alternating non-cross-resistant multiagent chemotherapy (ANCRC) and high-dose chemotherapy followed by autologous stem cell support (HDC-ASCS) in first remission to improve outcome in patients with ...
Ars Technica

AI used to design a multi-step enzyme that can digest some plastics

Enzymes are amazing catalysts. These proteins are made of nothing more than a handful of Earth-abundant elements, and they promote a vast array of reactions, convert chemical energy to physical motion ...

Resurrected ancient enzyme offers new window into early Earth and the search for life beyond it

By resurrecting a 3.2-billion-year-old enzyme and studying it inside living microbes, researchers at the University of ...