This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they ...

Patent foramen ovale is usually an incidental finding but can sometimes cause hypoxemia. Patent foramen ovale should be considered when the degree of hypoxemia is disproportionate to the underlying ...

Studies to date have shown an association between the presence of patent foramen ovale and cryptogenic stroke in patients younger than 55 years of age. This association has not been established in ...