The San Francisco 49ers face the New York Giants needing a win to rally amid another season threatening to be derailed by injuries. Here's what our NFL coverage team expects.

The banged-up Giants return home this week after two disheartening and frustrating road losses. They welcome the equally bruised 49ers, who travel from the west coast for a 1 p.m. ET start – always an advantage for the east coast team (although everyone gets an extra hour this Sunday morning – a boon for all you Big Blue tailgaters out there).

Yes, Kansas City Chiefs quarterback Patrick Mahomes dominates the Raiders: he's 12-2 against them with 33 passing touchdowns and only 5 interceptions. That's the best touchdown to interception ratio (6.6) by any quarterback versus a single team since at least 1950, minimum 500 pass attempts, per CBS Sports Research.

Detroit has the No. 1 defense per DVOA, and while the Vikings are typically known for a strong unit on that side of the ball, the stats do not back that up. Minnesota ranks 20th in defense per DVOA. It’s a middle-of-the-pack defense against one of the top rushing offenses.

NFL Week 9 is here, so let's look at the odds and make some picks and predictions for the next weekend of the 2025 regular season.

Giants' Thibodeaux and Lawrence face a tough 49ers offense. Can San Francisco's Gross-Matos, Huff, and Winters dominate the line? This game hinges on defensive dominance.

Preview the Houston Texans' NFL week 9 matchup with the Broncos, including betting odds, tips, trends, and game information.