Intrathecal drug administration via lumbar puncture and a spinal access port device led to serious complications in a patient receiving experimental therapy for Niemann-Pick type C. In a case report ...

Researchers have generated more preclinical evidence that intranasal delivery can get antibodies to the brain, presenting data that suggest the administration route can achieve concentrations close to ...

Panelists discuss how intrathecal delivery of onasemnogene abeparvovec in the STEER study demonstrates statistically significant motor function improvements in older patients with SMA (ages 2-18 years ...

Antisense oligonucleotide (ASO) therapy has the potential to ameliorate many neurodegenerative diseases at the genetic level to suppress the production of harmful proteins or non-coding RNAs.

An EU-backed initiative has assembled a team to develop a nose-to-brain biologics delivery device for neonates, enlisting medtech company Eveon and other groups to support Chiesi Farmaceutici. The ...

Real-world use of a CSF circulating tumor cell assay in the diagnosis and management of leptomeningeal metastasis. This is an ASCO Meeting Abstract from the 2024 ASCO Annual Meeting I. This abstract ...

Intrathecal chemotherapy is a form of cancer treatment in which a healthcare professional injects chemotherapy drugs into the cerebrospinal fluid (CSF). This colorless fluid surrounds the brain and ...