Laminins are heterotrimeric glycoproteins that form a fundamental scaffold within the extracellular matrix, particularly in basement membranes. Each laminin molecule comprises α, β and γ chains ...

Carcinogenesis is a multistep process that reflects an accumulation of genetic and epigenetic events leading to deregulated cellular growth control and to the acquisition of qualitatively new ...

The laminin-411 protein is vital for the formation of the myelin membrane by oligodendrocytes, report researchers from Japan. Furthermore, the A4G47 peptide from the E8 region of laminin-411 was found ...

The Feltri lab seeked to understand how cell-cell and cell-extracellular matrix interactions contribute to cell shape and polarity within a developing tissue. They applied these biological questions ...

Researchers have shown how the protein laminin, long thought to provide only structural support in the microenvironment of breast and other epithelial tissue, can play a leading role in the ...

Key to Derivation and Culture of Stem Cells and Differentiated Cells Lies with These ECM Proteins Researchers in the areas of regenerative medicine, basic biomedical research, and drug discovery all ...

Researchers at Institute of Science Tokyo have identified laminin-411 and A4G47, a synthetic peptide derived from the E8 domain of laminin-411 protein, as the key factors in the maturation of ...