Lysosomes play an important role in cells and tissues, controlling not only the degradation of substances but also cell division and growth. A team led by Professor Volker Haucke and Dr. Michael Ebner ...

Lysosomes, often reductively referred to as the "garbage disposals" of cells, play a pivotal role in our cells' digestive systems by getting rid of unwanted materials. Now in a groundbreaking study, ...

Lysosomes, since their discovery, have been primarily known for degrading cellular macromolecules. However, in recent studies, they have begun to emerge as crucial regulators of cell homeostasis. They ...

Over the last few decades, neurodegenerative diseases became one of the top 10 global causes of death. Researchers worldwide are making a strong effort to understand neurodegenerative diseases ...

Lysosomes require tight regulation of their pH to degrade their contents. Researchers know that V-ATPase pumps protons into these little digestive sacs, but what protein shuttles the ions back out?

Existing state-of-the-art models of human neurons often rely on the differentiation of induced pluripotent stem (iPS) cells. Although invaluable for studying genetic mutations in a relevant neuronal ...

Lysosomes are organelles that play essential roles in cellular digestion and waste management, and lysosomal dysfunction typically leads to serious diseases. In a recent study, scientists developed a ...

Our cells rely on tightly regulated signaling pathways to control when they grow, divide and survive. When these regulatory ...

Once thought of as having one simple job within cells, researchers continue to learn more about the importance of organelles called lysosomes. An organelle is a small structure in a cell that is ...

Because the STING protein has multiple functional regions spanning the cell membrane, the researchers did additional experiments to determine which region might be responsible for lysosome generation.

The duplication and division of cells is critical to keeping all multicellular organisms alive. But the opposite process is equally important: cell death. Controlled death of cells, or programmed cell ...

Ishikawa, Japan - The correct functioning of our cells rests upon the precise orchestration of many complex processes and organelles. Lysosomes—vital cell organelles—are enzyme-filled subunits found ...