The major histocompatibility complex (MHC) class I antigens are generally ubiquitously expressed and provide the identity to the host organism. 1, 2 Expression of these antigens on the cell surface ...

Major histocompatibility complex class II (MHC-II) molecules play a critical, yet historically overlooked, role in tumor immunity.

In a recent study posted to the bioRxiv* preprint server, researchers observed severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) downregulates the expression of major histocompatibility ...

Tumor mutational burden (TMB) and PD-L1 expression as predictors of response to immunotherapy (IO) in NSCLC. This is an ASCO Meeting Abstract from the 2019 ASCO Annual Meeting I. This abstract does ...

T cells have long been studied for their ability to target and eliminate tumor cells. In order for the T cells to do so, the tumors must express antigens not presented by healthy tissues, and the ...

Association of response to programmed death 1 receptor or ligand (PD1/PDL1) blockade with immune-related gene expression profiling across three cancer-types. This is an ASCO Meeting Abstract from the ...

Modifying the organ instead of the recipient isn’t a new idea, but it is an important one, said Jeffrey Platt, a transplantation biologist at the University of Michigan Medical School who was not ...

Cancer immunotherapy has transformed cancer treatment, yet many patients experience limited or short-lived responses due to immune evasion, tumor heterogeneity, and immune-related adverse events.