A Purdue University team has discovered a new therapeutic target for triple-negative breast cancer. The research, led by Kyle ...

Phosphorylation, a pivotal post‐translational modification, regulates a wide array of cellular processes by the covalent attachment of phosphate groups to proteins. This modification, largely executed ...

Researchers at Nano Life Science Institute (WPI-NanoLSI) and the Cancer Research Institute at Kanazawa University have ...

Protein kinase inhibitors represent a major advance in cancer treatment due to their ability to target the specific kinases involved in tumor growth and survival. More than 80 small-molecule protein ...

NOTE. P < .00357 represents statistical significance after the Bonferroni correction. Abbreviations: MAPK, mitogen-activated protein kinase; NA, unable to be calculated; NR, not reached; OS, overall ...

Researchers visualized ALK fusion proteins in real time. They showed that ALK inhibitors reshape flexible protein regions to ...

As society ages, the number of patients with heart failure is rapidly increasing. The progression of the disease is caused by excessive growth of fibrotic tissue in the heart, known as fibrosis. A ...

The development of new therapeutics targeting protein kinases is crucial in the fight against diseases like cancer.

If cells are the factories, proteins are the workers. They control nearly every aspect of cell function, from structure to signaling, from transport to defense. And, like many workers, they rarely act ...

Protein kinases are the molecular switches of the cell. They control growth, division, communication, and survival by attaching phosphate groups to other proteins. When these switches are stuck in the ...