To function normally, nearly every cell in the human body relies on G-protein coupled receptors (GPCRs) to receive and send ...

Protein networking is critical to understanding the biological functions of proteins and the underlying mechanisms of disease. However, identifying physical protein–protein interactions (PPIs) can be ...

After nearly four decades of research, Mayo Clinic scientists have revealed the molecular structure of protein kinase C beta (PKCβ), a key protein linked to cancer and neurological diseases. The ...

Targeted protein degradation (TPD) aims at reprogramming the target specificity of the ubiquitin–proteasome system, the major cellular protein disposal machinery, to induce selective ubiquitination ...

Undruggable targets typically refer to a class of therapeutic targets that are difficult to target through conventional methods or have not yet been targeted, but are of great clinical significance.