CRISPR–Cas13—a class 2 type VI RNA endonuclease with two higher eukaryotes and prokaryotes nucleotide-binding (HEPN) domains for RNA cleavage—targets and degrades RNA. The RNA targeting has been used ...
Assessments of DNA misrepair, and the resulting effects on the structural integrity of the genome, are critical for evaluating the safety of cell and gene therapy applications. Most genome editing ...
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