When the molecular machinery in our cells gets to work transcribing the genetic information encoded in DNA into messenger RNA (mRNA), it pauses shortly after starting. Known as promoter-proximal ...

New research reveals that a fundamental process in bacterial gene regulation called sigma cycle, long thought to involve the release of a key protein, sigma factor, might not be universal, opening new ...

A cell protein previously believed only to provide a scaffolding for DNA has also been shown to directly influence DNA transcription into RNA – the first step of the process by which an organism's ...

Every living cell must interpret its genetic code - a sequence of chemical letters that governs countless cellular functions. A new study by researchers from the Center for Theoretical Biological ...

Intrinsically disordered regions in transcription factors enhance both target binding probability and search efficiency.