Lupus Science & Medicine

Psychometric validation of the Bengali Lupus-QoL and its correlation with disease activity, damage and low disease activity state: a two-centre cross-sectional study

Background SLE is a complex autoimmune condition requiring evaluation across disease activity, permanent damage and ...
Lupus Science & Medicine

Suboptimal attainment of SLE treat-to-target goals based on persistently high physician global assessment: an analysis of German SPOCS patients

Objective Systemic lupus erythematosus Prospective Observational Cohort Study (SPOCS) was a prospective observational study ...
lupus.bmj

Infertility in systemic lupus erythematosus: what rheumatologists need to know in a new age of assisted reproductive technology

Fertility is often a concern for women with SLE. In addition to known indirect factors that influence the ability of a woman with SLE to become pregnant, such as cytotoxic agents, other medications, ...
lupus.bmj

Efficacy of belimumab in patients with SLE and haematological manifestations: retrospective analysis from the BeRLiSS 2.0 cohort

Objective To assess the effectiveness of belimumab (BEL) in improving anaemia, thrombocytopenia, lymphopenia and leucopenia in patients with SLE. Conclusion In this real-world cohort, BEL treatment ...
lupus.bmj

PO:11:292 Preclinical evaluation of IRF5 small molecule inhibitors with potent activity in lupus-relevant systems

Objectives Dysregulated IRF5 activity drives type I interferon, pathogenic cytokine production, and B cell activation and differentiation downstream of TLR7/8/9 signaling, contributing to systemic ...
lupus.bmj

Quantifying the burden of steroid-related damage in SLE in the Hopkins Lupus Cohort

Objective Corticosteroids are a mainstay of SLE treatment; however, cumulative steroid exposure may lead to organ damage. This study aimed to quantify the risk of new diabetes, hypertension, cataracts ...
lupus.bmj

Discoid lupus erythematosus skin lesion distribution and characteristics in Black patients: a retrospective cohort study

Objective Epidemiological studies have shown that discoid lupus erythematosus (DLE) has a higher incidence and prevalence in racial/ethnic minority groups, particularly Black individuals. The ...
lupus.bmj

Belimumab versus telitacicept in sequential treatment after rituximab for refractory lupus nephritis: a real-world multicentre study

Objective Both belimumab and telitacicept are recognised blockers for B lymphocyte activation, both of which have been approved as add-on therapies for SLE in China. The aim of this study is to ...
lupus.bmj

Hospitalised infections and rituximab administration among children and adolescents with systemic lupus erythematosus from 2009 to 2021

Background Rituximab is associated with high infection rates, but studies of infections following rituximab in youth with childhood-onset SLE (cSLE) are limited. We conducted a retrospective ...
lupus.bmj

Fatigue outcomes with anifrolumab in low-disease-activity SLE: DNA damage in plasmacytoid dendritic cells as a candidate biomarker for responders

Objective Investigate the effect of anifrolumab on fatigue in patients with SLE and low disease activity and identify cellular mechanisms associated with the fatigue response. Methods 12 SLE patients ...
lupus.bmj

Prospective evaluation assessing the influence of outcome definition, cohort inclusion and DORIS remission in predicting adverse pregnancy outcomes in women with systemic lupus ...

Objective Systemic lupus erythematosus (SLE) is associated with increased risk for adverse pregnancy outcomes (APOs). The Predictors of Pregnancy Outcomes: Biomarkers in Antiphospholipid Syndrome and ...