Researchers discovered how coccolithophores, a subset of haptophytes, harness the sun's energy, which could lead to ...

Here we use cryogenic electron microscopy to determine the structure of TbAQP2 from Trypanosoma brucei, bound to either the substrate glycerol or to the sleeping sickness drugs, pentamidine or ...

Cryogenic electron microscopy (cryoEM) faces challenges such as particle aggregation, preferential orientation, and loss at ...

Based on several lines of interesting data, the authors conclude that FMRP, though associated with stalled ribosomes, does not determine the position on the mRNAs at which ribosomes stall. Although ...

In 1977, the Nobel Prize in Physiology or Medicine was awarded to Roger Guillemin and Andrew Schally for their discovery and synthesis of gonadotropin-releasing hormone (GnRH), a key regulator of ...

Scientists have mapped the molecular structure of glutamate receptors in the cerebellum for the first time using ...

Sample loss has been a persistent problem in cryo-EM, a high-tech method for creating 3D models of molecules that reveal their inner structures. It occurs during an essential step of imaging ...

Now, UCLA biochemists, working with pharmaceutical industry scientists, have developed a solution that will make it possible for cryo-EM to acquire high-quality images of smaller protein molecules, ...

Top-of-the-line cryo-EM instruments operate at voltages of 300 keV and cost about $5–7 million. Less powerful instruments are being developed that operate at around 100 keV.

Cryogenic electron microscopy (cryo-EM) is a variant of electron microscopy that uses cryogenically cooled samples that have been ‘flash frozen’. Cryo-EM methods have proved revolutionary in the life ...

Another key advantage of cryo-EM is the reduced sample damage. Many of the original developments in cryo-EM were motivated by biological imaging applications. Biological samples can be fragile and ...

As cryo-EM is used to accumulate the many high-resolution images of proteins that are needed to achieve a good three-dimensional reconstruction of a protein, the amount of data, Kolbeck notes, is ...