Trained immunity provides a unifying framework linking innate immune memory to both protective and maladaptive inflammation ...
Distinct patterns of SARS-CoV-2 viral dynamics in saliva reveal heterogeneity that cannot be sufficiently explained by conventional clinical characteristics or microRNA profiles alone.
CDK2-mediated TBK1 degradation via Dtx4 represents a previously unrecognized regulatory mechanism that modulates antiviral immunity in fish.
BK and CaV1.3 channels interact early during biogenesis, assembling intracellularly before membrane localization, indicating coordinated processes for functional coupling.
Lipid imbalance triggered by Snail-driven epithelial–mesenchymal transition creates a cholesterol-dependent vulnerability that can be therapeutically targeted to overcome chemoresistance in cancer.
A large-scale investigation of carnivoran brain diversity, providing a unified description of folding patterns, their relationship to behaviour and ecology, and the foundation for future ...
This important study, which tackles the challenge of analyzing genome integrity and instability in unicellular pathogens by introducing a novel single-cell genomics approach, presents compelling ...
An agreement between universities, research institutes and funders to support the career development of researchers in the UK has led to improvements in research culture since 2019, but there is still ...
Machine learning models reveal that histone marks are predictive of gene expression across human cell types and highlight important nuances between natural control and the effects of CRISPR-Cas9-based ...
Non-coding DNA is essential for both humans and trypanosomes, despite the large evolutionary divergence between these two species.
A shift in the balance between two lipids – cholesterol and sphingomyelin – makes hybrid epithelial-mesenchymal cancer cells less responsive to certain chemotherapy drugs.
Exosome-associated THSD7A is identified as a key trigger of filopodia formation in cancer cells and neurons, revealing a ...
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