Fibrosis and accumulation of senescent cells are common tissue changes associated with aging. Here, we show that the CDK ...

In this issue, Papismadov et al (2024) report that p21 (CDKN1A), known to activate the senescence growth arrest, also ...

The systemic regulation of metabolic dysfunction-associated liver disease remains poorly understood. In this issue, Hsiao et ...

The liver function in post-cardiac arrest brain injury is not known and was investigated in a pig model of global cerebral ...

The time bomb of misinformation and disinformation will have exploded, taking with it our ability to think for ourselves.

Astrocytes in the brain exhibit significant regional diversity, but the mechanisms controlling their heterogeneity remain ...

RPE-1 cells adapt to aneuploidy in vitro, a process characterized by reduced CIN and inflammation. This study shows that this ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Z-DNA-binding protein 1 (ZBP1) is an ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The physiological significance of enzymatic ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Aurora-A is an essential cell-cycle kinase ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Evidence suggests mitochondrial homeostasis ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Lamina-associated domains (LADs) are large ...