The EMBO Journal1d
p21 regulates expression of ECM components and promotes pulmonary fibrosis via CDK4 and Rb
Fibrosis and accumulation of senescent cells are common tissue changes associated with aging. Here, we show that the CDK ...
The EMBO Journal1d
Cellular senescence, p21, and the path to fibrosis
In this issue, Papismadov et al (2024) report that p21 (CDKN1A), known to activate the senescence growth arrest, also ...
The EMBO Journal12d
Liver protects neuron viability and electrocortical activity in post-cardiac arrest brain injury
The liver function in post-cardiac arrest brain injury is not known and was investigated in a pig model of global cerebral ...
The EMBO Journal6d
BATokines in metabolic liver disease: good cops or bad cops?
The systemic regulation of metabolic dysfunction-associated liver disease remains poorly understood. In this issue, Hsiao et ...
The EMBO Journal12d
Astrocyte allocation during brain development is controlled by Tcf4-mediated fate restriction
Astrocytes in the brain exhibit significant regional diversity, but the mechanisms controlling their heterogeneity remain ...
The EMBO Journal6d
Time bomb
The time bomb of misinformation and disinformation will have exploded, taking with it our ability to think for ourselves.
The EMBO Journal13d
Reduction of chromosomal instability and inflammation is a common aspect of adaptation to aneuploidy
RPE-1 cells adapt to aneuploidy in vitro, a process characterized by reduced CIN and inflammation. This study shows that this ...
The EMBO Journal13d
A shorter splicing isoform antagonizes ZBP1 to modulate cell death and inflammatory responses
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Z-DNA-binding protein 1 (ZBP1) is an ...
The EMBO Journal5d
A novel bacterial effector protein mediates ER-LD membrane contacts to regulate host lipid droplets
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The intracellular bacterial pathogen Coxiella ...
The EMBO Journal7d
Combining systems and synthetic biology for in vivo enzymology
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The physiological significance of enzymatic ...
The EMBO Journal7d
Chromatin protein complexes involved in gene repression in lamina-associated domains
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Lamina-associated domains (LADs) are large ...
The EMBO Journal5d
Mutation in the mitochondrial chaperone TRAP1 leads to autism with more severe symptoms in males
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Evidence suggests mitochondrial homeostasis ...