CME activities, cases, challenges, videos, and more teaching and learning tools from the New England Journal of Medicine.

TRADITION is hard to break. Doubtless since the time of Adam, dropsy has been traditionally treated by the limitation of fluid intake, a natural result of the observation of the accumulation of ...

An estimated 20 to 40% of patients with chronic obstructive pulmonary disease (COPD) have signs of eosinophilic inflammation, a condition that is characterized by an increased blood eosinophil ...

The β 2 common integrin subunit CD18 is essential for leukocyte–endothelial adhesion and extravasation to inflamed or infected tissue. Damaging variants in ITGB2, which encodes CD18, cause ...

Shown are the genetic variants identified in EPO, the gene encoding erythropoietin (EPO), in patients with erythrocytosis. The term cDNA denotes complementary DNA, F female, M male, and NA not ...

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when ...

Resolution of steatohepatitis without worsening of fibrosis occurred in 62.9% of the 534 patients in the semaglutide group and in 34.3% of the 266 patients in the placebo group (estimated ...

Alcohol policy interventions, including those that increase alcohol taxes, raise the drinking and purchase age, reduce days or hours of sale, and impose strong marketing bans, reduce alcohol ...

In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information by sharing relevant background and ...

Relapsed Burkitt’s lymphoma is nearly always fatal. Three patients had a complete metabolic response with the combination of the bispecific antibody glofitamab and the antibody–drug conjugate ...

In patients with COPD, eosinophilic inflammation leads to exacerbations, with increased use of health care resources and mortality. New research findings with mepolizumab treatment are summarized ...