A new study led by Rice University's Pernilla Wittung-Stafshede has revealed that protein clumps, or plaques that clog the brain, associated with Parkinson's disease are not merely waste; they can ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. A computational study of p97/VCP ATPase using hybrid quantum mechanics/molecular ...

ATP has many functions in the body, including neurotransmission, DNA and RNA synthesis, intracellular signaling, and muscle contraction. It can also be used clinically in pain management, anesthesia, ...

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CFTR, the anion channel mutated in cystic fibrosis patients, is a model ABC protein whose ATP-driven conformational cycle is observable at single-molecule level in patch-clamp recordings. Bursts of ...

F-Type ATP synthase, a catalytic complex of proteins, synthesizes adenosine triphosphate (ATP), the energy currency of living cells. A lot of ambiguity exists over the rotational mechanism of this ...

Kinesin, an amazing biological machine, converts chemical energy from the ATP hydrolysis into mechanical energy to perform different cellular activities. Several single-point gene-level mutations in ...

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One-dimensional (1D) target search is a well-characterized phenomenon for many DNA-binding proteins but is poorly understood for chromatin remodelers. Herein, we characterize the 1D scanning ...

Department of Physiology and Cell Biology, University of Nevada Reno School of Medicine, Reno, NV, United States FIGURE 1. Principal pathways of extracellular ATP hydrolysis. ATP is hydrolyzed to ADP ...