Nature

Control of thymocyte development and recombination-activating gene expression by the zinc finger protein Zfp608

Figure 1: Wasting syndrome, premature mortality and T cell immunodeficiency in homozygous ZORI mice. Figure 2: Thymocyte subpopulations in BALB/c and ZORI mice. Figure 3: Overexpression of Zfp608 mRNA ...

Potent DNA-recombination method developed for large cargo delivery in gene therapy

Delivery of therapeutic genes is essential for gene therapy. Adeno-associated viruses (AAVs) are a prime vector for carrying ...
Nature

AID expression increased by TNF-α is associated with class switch recombination of Igα gene in cancers

The only resource of immunoglobulin (Ig) molecules has traditionally been believed to be from B lymphocytes. In humans, all cells include germ line (GL) Ig genes, which comprise several V, D, J, and C ...
ascopubs.org

Association of homologous recombination deficiency in ovarian cancer with neoantigen load and expression of immune checkpoints.

Safety assessment of niraparib individualized starting dose in patients with platinum-sensitive recurrent ovarian cancer: A randomized, double-blind, placebo-controlled, phase III NORA trial. This is ...
Labmate Online

AAVLINK platform has enabled accurate delivery of therapeutic genes to the nervous system

Researchers in China have reported a novel adeno-associated virus strategy that enables efficient in vivo reassembly and expression of large therapeutic genes, addressing a long-standing ...