The San Francisco 49ers (9-4) will face the Tennessee Titans (2-11) in Week 15 at Levi’s Stadium, with all eyes on star running back Christian McCaffrey. McCaffrey was a late addition to the injury report on Saturday with a back issue, earning a questionable designation.

The Tennessee Titans and San Francisco 49ers face off in Week 15 of the NFL regular season today. Here's where to watch and start time.

RB Christian McCaffrey is expected to play vs. the Titans despite a questionable tag, with multiple NFL insiders signaling good news.

Sunday’s game at Levi’s Stadium could get out of hand quickly. The San Francisco 49ers will host the Tennessee Titans as 12.5-point favorites in Week 15. The un

The San Francisco 49ers have placed receiver Brandon Aiyuk on the reserve/left squad list, making him ineligible to return from a knee injury this season.

The Tennessee Titans play the San Francisco 49ers in Week 15 of the NFL season.

The San Francisco 49ers made a significant decision on wide receiver Brandon Aiyuk that could spell the end of his tenure in the Bay Area.