🦴 Case Study 189: Ankylosing Spondylitis (AS) Chronic back pain in a 24-year-old female, worse in the morning, improving with activity. After years of misdiagnoses and dismissals, the answer finally came: Ankylosing Spondylitis. 📊 Key Facts: • 🕒 Avg delay to diagnosis: 6–8 years, especially in women • 🔍 HLA-B27: Positive in ~90% of White patients with AS, but less common in Black and Asian patients • 📈 Prevalence: ~0.1–1.4% globally • 🧠 Often missed due to gradual onset, subtle early signs
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